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Basaloid follicular hamartoma syndrome

A rare genetic syndrome with multiple small flesh-colored papules, alopecia, and characteristic punctate pits on the palms and soles.

Cowden disease

A PTEN hamartoma syndrome with multiple facial trichilemmomas and acral keratoses, which can include small palmar pits.

Darier's disease

A genetic disorder that can cause keratotic papules and pits on the palms and soles, in addition to its characteristic flexural lesions.

Gorlin syndrome

A genetic disorder (nevoid basal cell carcinoma syndrome) with a classic finding of multiple, small, discrete pits on the palms and soles.

Pitted keratolysis

A bacterial infection of the soles causing malodorous, superficial, confluent, 'punched-out' pits in the stratum corneum.

Punctate palmoplantar keratoderma

An inherited keratoderma characterized by multiple, small, discrete, keratotic plugs on the palms and soles that fall out, leaving pits.

Punctate porokeratosis

A variant of porokeratosis with multiple, tiny, seed-like, annular macules with a fine keratotic rim, on the palms and soles.

Reticulate acropigmentation of Kitamura

A genetic disorder with reticulated (net-like) hyperpigmentation on the backs of the hands and feet, and small pits on the palms.

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