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Apthous ulcer

Aphthous ulcers occur randomly inside the mouth, whereas a fixed drug eruption is defined by its recurrence in the exact same location upon re-exposure to a specific drug.

Behcet's disease

Behcet's involves recurrent oral and genital ulcers, but they are not fixed to a single location and are part of a systemic vasculitis.

Chancroid

This is an infectious genital ulcer, not a recurrent, drug-induced lesion.

Granuloma inguinale

This is a chronic, progressive, "beefy-red" bacterial ulcer, a completely different morphology and etiology than a recurrent FDE plaque.

Syphilis

A syphilitic chancre is a primary infectious ulcer, not a recurrent, drug-induced lesion.

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