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Discoid lupus erythematosis

DLE plaques are more erythematous, have adherent scale, follicular plugging, and lead to more significant atrophy, unlike the brownish, "apple-jelly" nodules of lupus vulgaris.

Rosacea

Lupus pernio, a form of sarcoidosis, can mimic rosacea, but lupus vulgaris (TB) is a destructive, ulcerative, or nodular plaque.

Sarcoidosis

Both can have reddish-brown plaques with "apple-jelly" nodules on diascopy, but lupus vulgaris is caused by Mycobacterium tuberculosis and is confirmed by finding the organism on culture or PCR.

Tinea faciale

This is a superficial fungal infection with a scaly, annular border, a completely different pathology than the deep, granulomatous, and destructive plaque of lupus vulgaris.

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