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Calcinosis

Calcinosis cutis is a hard, rock-like deposit, unlike the soft, fleshy texture of a neurofibroma.

Dermoid cyst

A dermoid cyst is a firm, fixed, congenital nodule, whereas a neurofibroma is a soft tumor that often has the "buttonhole" sign.

Epidermoid cyst

An epidermoid cyst is a firm, keratin-filled nodule with a central punctum, unlike a soft, solid neurofibroma.

Eruptive xanthomas

These are multiple, yellowish papules related to hyperlipidemia, not soft, skin-colored nodules.

Lipoma

A lipoma is a soft, lobulated fat tumor in the subcutis, feeling different from the more discrete, fleshy dermal neurofibroma.

Lymph node

A lymph node is a discrete, bean-shaped structure in a lymphatic basin, not a primary skin tumor like a neurofibroma.

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