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Dermatofibromas

These are firm dermal nodules that do not typically have a central keratotic plug or evidence of transepidermal elimination.

Discoid lupus erythematosus

The plaques of DLE are characterized by adherent scale and follicular plugging, not the central keratotic plug of a perforating disorder.

Excoriations

These are linear scratches, a form of trauma, not primary papules with a central keratotic core.

Folliculits

Folliculitis is an inflammatory pustule centered on a hair follicle, not a papule with a keratotic plug.

Granuloma annulare

Perforating GA is a specific subtype, but classic GA is a non-perforating annular plaque.

Insect bite reaction

A bite reaction is a pruritic papule that may be excoriated, but it does not have a primary keratotic core.

Multiple keratoacanthomas

KAs are rapidly growing, crateriform nodules with a large keratin plug, a much larger and more dramatic lesion than the papules of perforating disorders.

Nodular prurigo

These are intensely itchy, firm nodules, but they do not have the characteristic central umbilication with a keratotic plug seen in perforating dermatoses.

Porokeratosis

This is characterized by a distinct, thread-like, raised border (the cornoid lamella), a different morphology.

Sarcoidosis

Perforating sarcoidosis is a rare variant, but typical sarcoid lesions are non-perforating papules or plaques.

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