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Adenovirus

Often associated with prominent respiratory symptoms (pharyngitis, conjunctivitis) in addition to fever and rash.

EBV

Infectious mononucleosis can cause an exanthem, but it is typically accompanied by significant pharyngitis, posterior cervical lymphadenopathy, and splenomegaly.

Enterovirus

Associated with rashes like hand-foot-and-mouth disease or herpangina, which have a characteristic distribution and morphology not seen in roseola.

Measles

Distinguished by the '3 Cs' (cough, coryza, conjunctivitis) and Koplik spots preceding a rash that starts on the head and moves down.

Parvovirus

Causes erythema infectiosum (fifth disease), recognized by the classic 'slapped cheek' facial rash followed by a lacy, reticular rash on the body.

Rubella

Presents with a milder prodrome, prominent postauricular and occipital lymphadenopathy, and a maculopapular rash that spreads more rapidly than measles.

Rubeola

Another name for Measles, distinguished by the prodrome of cough, coryza, conjunctivitis, and the presence of Koplik spots.

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