Begins as a painless, pruritic papule that rapidly evolves into a vesicle, then a hemorrhagic bulla, and finally a characteristic black, depressed, anesthetic eschar.
An autoimmune disorder that can cause necrosis secondary to thrombosis, often presenting as livedo reticularis, purpura, or painful ulcerative lesions.
Can cause indolent nodules that may break down to form chronic, ulcerative lesions with surrounding necrosis.
A condition of vascular calcification and thrombosis, leading to intensely painful, violaceous, retiform purpura that progresses to necrotic ulcers with black eschars, typically in patients with renal failure.
A small-vessel vasculitis that can lead to ischemic necrosis of the skin, particularly on acral sites like fingertips, toes, and the nose.
A systemic clotting disorder that consumes platelets and clotting factors, leading to widespread purpura and large areas of hemorrhagic necrosis.
Localized skin necrosis at an IV site caused by the leakage of a vesicant drug (like chemotherapy) into the surrounding tissue.
A cutaneous sign of Pseudomonas aeruginosa sepsis, beginning as a painless red macule that becomes a hemorrhagic pustule and then a gangrenous ulcer with a central black eschar.
Sepsis with Neisseria meningitidis can cause rapidly progressing, large, stellate or map-like areas of purpura fulminans with central grey necrosis.
Inflammation of subcutaneous fat associated with pancreatic disease, presenting as tender nodules that can ulcerate and discharge an oily, necrotic substance.
A life-threatening condition of DIC and cutaneous necrosis, presenting as large, sharply marginated areas of hemorrhagic necrosis, often on the extremities.
Severe, prolonged vasospasm in Raynaud's can lead to ischemic necrosis, presenting as small, exquisitely painful ulcers or gangrene at the very tips of the digits.
The bite of a cytotoxic snake can cause rapid local swelling, ecchymosis, and a central area of hemorrhagic necrosis around the fang marks.
The bite of a brown recluse spider classically causes a lesion with a central violaceous area that becomes necrotic, surrounded by a pale ring of ischemia and an outer red ring of inflammation.
Inflammation of blood vessels can compromise blood flow, leading to palpable purpura that may evolve into hemorrhagic bullae and necrotic ulcers.
