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Acquired plantar keratoderma

Diffuse or focal thickening of the skin on the soles of the feet that develops in adulthood, often as a paraneoplastic sign.

Corn

A well-demarcated, cone-shaped area of hyperkeratosis over a bony prominence, caused by friction and pressure, which has a hard, painful central core.

Crusted scabies

A hyperinfestation with scabies mites in an immunocompromised host, leading to a widespread, thick, crusted, hyperkeratotic dermatitis that can be prominent on the feet.

Eczema

Chronic hand and foot eczema can lead to a hyperkeratotic, fissured dermatitis (tylotic eczema).

Keratoderma

A general term for marked thickening of the palms and soles, which can be inherited or acquired, and diffuse, focal, or punctate.

Keratoderma blennorrhagicum

A skin manifestation of reactive arthritis, presenting as crusted, hyperkeratotic, waxy papules and plaques on the soles.

Pitted keratolysis

A bacterial infection of the soles causing malodorous, superficial, "punched-out" pits in the stratum corneum.

Psoriasis

Palmoplantar psoriasis presents as well-demarcated, erythematous plaques with thick, yellowish, hyperkeratotic scale on the soles.

Tylosis

An older term for inherited diffuse palmoplantar keratoderma, particularly the non-epidermolytic form associated with esophageal cancer.

Viral wart

A plantar wart (verruca plantaris) is a hyperkeratotic papule on the sole that disrupts normal skin lines and may have black dots (thrombosed capillaries).

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