Presents as recurrent, painful, shallow, round ulcers with a yellowish-gray base and an erythematous halo, identical to canker sores in the mouth.
A systemic vasculitis characterized by recurrent oral and genital aphthous ulcers, along with eye and skin lesions.
A form of squamous cell carcinoma in situ, which can present as a persistent, red, scaly plaque or a shallow ulceration.
A sexually transmitted infection (Haemophilus ducreyi) causing one or more deep, painful, soft ulcers with ragged, undermined edges and a gray, necrotic base.
A rare manifestation of Epstein-Barr virus, typically in immunocompromised individuals, presenting as a single, well-demarcated, "punched-out" ulcer.
An autoimmune blistering disease that can cause erosions and ulcers on mucosal surfaces, which tend to heal with scarring.
A severe variant of lichen planus causing painful, chronic, bright red erosions and ulcers on the genital and oral mucosa.
An acute hypersensitivity reaction that can cause erosions and ulcers on mucosal surfaces, often along with classic "target" lesions on the skin.
A drug reaction that characteristically recurs in the exact same location as a well-demarcated, dusky red or violaceous plaque that often blisters and erodes.
A sexually transmitted infection (Klebsiella granulomatis) causing painless, progressive, ulcerative lesions that are beefy-red and bleed easily ("donovanosis").
A genetic blistering disease with painful, recurrent erosions, macerated plaques, and fissures in intertriginous areas like the groin.
A common sexually transmitted infection causing clusters of small, painful vesicles that rupture to form shallow, grouped ulcers on an erythematous base.
A rare neoplastic disorder that can present as "punched-out" ulcerative or seborrheic-like lesions in the genital area.
A chronic inflammatory condition that can cause atrophic white plaques, but also painful fissures, erosions, and ulcers in the anogenital region.
A sexually transmitted infection (Chlamydia trachomatis) that starts with a small, painless, transient ulcer, followed by painful, suppurative inguinal lymphadenopathy (buboes).
An autoimmune disease primarily causing scarring blisters and erosions on mucous membranes, including the genitals.
Pemphigus vulgaris often involves mucosal surfaces, causing flaccid blisters that rapidly evolve into painful, persistent erosions and ulcers.
A malignant tumor presenting as a persistent, firm, indurated, warty, or ulcerative lesion that fails to heal.
A severe mucocutaneous drug reaction characterized by widespread hemorrhagic erosions and ulcers of the genital, oral, and ocular mucosa.
Primary syphilis presents as a single, painless, firm, clean-based ulcer (chancre) with an indurated border.
Rarely, tuberculosis can cause genital ulcers, which are typically ragged, undermined, and associated with caseous necrosis.
A benign inflammatory condition of the glans penis in uncircumcised men, presenting as a solitary, well-demarcated, shiny, moist, red-orange plaque.
