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Annular elastolytic giant cell granuloma

Characterized by annular plaques with a slightly raised papular border and a distinct atrophic, wrinkled center, often in sun-exposed areas.

Chron's disease

Metastatic Crohn's disease can cause granulomatous nodules, plaques, or ulcers on the skin, distant from the gastrointestinal tract.

Granuloma annulare

Presents as a ring of firm, skin-colored or erythematous papules without any surface scale, resulting from palisading granulomas in the dermis.

Granulomatous slack skin

A very rare variant of CTCL characterized by the slow development of pendulous, lax, and wrinkled folds of skin in intertriginous areas.

Necrobiosis lipoidica

Typically on the shins, this condition presents as a waxy, atrophic, yellowish plaque with a violaceous, raised border, showing a layered or 'tiered' granuloma on histology.

Necrobiotic xanthogranuloma

Presents as yellowish or red-brown plaques and nodules that tend to ulcerate, often in the periorbital region and associated with a monoclonal gammopathy.

Rheumatoid nodule

A firm, non-tender, subcutaneous nodule over a joint, which histologically is a palisading granuloma with a central area of fibrinoid necrosis.

Ruptured epidermoid cyst

The release of keratin into the dermis from a ruptured cyst elicits a foreign-body giant cell granulomatous reaction.

Sarcoidosis

The classic non-caseating granulomatous disease, presenting on skin as reddish-brown or violaceous papules and plaques, which show a classic 'apple-jelly' color on diascopy.

Syphilis

Tertiary syphilis causes a destructive, caseating granulomatous lesion called a gumma.

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