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Churg-Strauss syndrome

A small-vessel vasculitis associated with asthma and eosinophilia, which can cause purpuric papules and nodules.

Cryoglobulinaemia

A vasculitis caused by immune complexes that precipitate in the cold, classically presenting with palpable purpura on the lower extremities.

Erythema multiforme

The characteristic target lesions can sometimes have a purpuric center, but are not primarily a purpuric rash.

Henoch-Schoenlein purpura

The classic childhood vasculitis, causing a symmetric eruption of palpable purpura on the buttocks and lower extremities.

Leukocytoclastic vasculitis

The prototypical small-vessel vasculitis, where palpable purpura is the hallmark lesion, caused by inflammation and destruction of vessel walls.

Microscopic polyangiitis

A systemic small-vessel vasculitis, often ANCA-positive, that frequently presents with palpable purpura on the lower legs.

PLEVA

Pityriasis lichenoides et varioliformis acuta presents with papules that develop a hemorrhagic or purpuric center before crusting.

Polyarteritis nodosa

A medium-vessel vasculitis that causes subcutaneous nodules and starburst-shaped purpura (livedo racemosa), rather than typical palpable purpura.

Septic emboli

Can cause purpuric macules, papules, and pustules on the extremities, often with a necrotic or gunmetal-gray center.

Swimmer's itch

Also called cercarial dermatitis, this is a parasitic infestation causing an itchy papular eruption, not purpura.

Urticarial vasculitis

Presents as urticarial-like wheals that are distinguished by lasting longer than 24 hours, being painful, and leaving behind purpura or pigmentation.

Waldenstroms hyperglobulinemic purpura

A benign condition with recurrent crops of petechiae and purpura on the lower legs, especially in women, due to hypergammaglobulinemia.

Wegener's granulomatosis

Now Granulomatosis with Polyangiitis, this vasculitis classically involves the respiratory tract and kidneys, but can cause palpable purpura on the skin.

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