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Alpha 1 antitrypsin deficiency

A genetic disorder that can cause a severe, necrotizing panniculitis with tender erythematous nodules that ulcerate and drain an oily discharge.

Cold panniculitis

Inflammation of subcutaneous fat after cold exposure, presenting as indurated, tender, erythematous nodules, classically on the cheeks of children ('popsicle panniculitis').

Erythema induratum

A lobular panniculitis, often associated with tuberculosis, presenting as tender, violaceous nodules on the posterior lower legs (calves) that frequently ulcerate.

Erythema nodosum

A septal panniculitis presenting as the sudden onset of tender, erythematous, non-ulcerating subcutaneous nodules on the anterior lower legs (shins).

Factitial panniculitis

Panniculitis caused by self-injection of foreign substances, often presenting as bizarrely shaped, sterile or infected nodules and abscesses.

Infective panniculitis

Panniculitis caused by direct inoculation of bacteria or fungi into the subcutaneous fat, leading to an abscess.

Lipodermatosclerosis

A chronic panniculitis associated with venous insufficiency, where the lower legs become fibrotic, hyperpigmented, and hardened, resembling an 'inverted champagne bottle'.

Lupus profundus

A panniculitis associated with lupus, presenting as firm, deep, subcutaneous nodules that heal with a characteristic depressed, atrophic scar.

Pancreatic panniculitis

Inflammation of subcutaneous fat associated with pancreatic disease, presenting as tender nodules that can ulcerate and discharge an oily, necrotic substance.

Panniculitis of dermatomyositis

A rare manifestation of dermatomyositis, presenting as painful, subcutaneous nodules that may ulcerate and show calcification.

Panniculitis of morphea

A deep form of morphea (scleroderma) that primarily involves the subcutaneous fat, causing indurated plaques.

Subcutaneous panniculitis-like T cell lymphoma

A rare lymphoma that mimics panniculitis, presenting as multiple, deep-seated, subcutaneous nodules and plaques, primarily on the legs and trunk.

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