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Bloom syndrome

A rare genetic disorder with sun-sensitive telangiectatic erythema on the face that evolves into poikiloderma, along with short stature and cancer risk.

Cockayne syndrome

A rare progeroid syndrome with a photosensitive rash that develops into poikiloderma, along with neurologic impairment and a 'cachectic dwarfism' appearance.

Dyskeratosis congenita

A rare genetic syndrome with a classic triad of nail dystrophy, oral leukoplakia, and a distinctive, reticulated (net-like) poikiloderma on the neck and chest.

Mycosis fungoides

The plaque stage of this cutaneous T-cell lymphoma can develop poikilodermatous features (atrophy, telangiectasia, pigment change) within the lesions.

Poikiloderma atrophicans vasculare

An archaic term for a presentation that is now considered a form of poikilodermatous mycosis fungoides or connective tissue disease.

Poikiloderma of Civatte

A common condition of chronic sun damage on the sides of the neck, with a characteristic mottled pattern of redness, hyper- and hypopigmentation, sparing the shaded area under the chin.

Rothmund Thompson syndrome

A rare genetic disorder with a characteristic poikilodermatous photosensitive rash in infancy, skeletal abnormalities, and increased cancer risk.

Xeroderma pigmentosa

A genetic DNA repair disorder that leads to severe sun sensitivity and the early development of freckle-like hyperpigmentation and guttate hypopigmentation, creating a poikilodermatous appearance.

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