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Anthrax

Can cause a primary eschar with marked surrounding edema and ascending lymphangitis.

Atypical mycobacterial infection

The classic 'fishtank granuloma' (Mycobacterium marinum) commonly presents as a primary nodule on the hand followed by secondary nodules ascending up the arm along lymphatic channels.

Blastomycosis

This deep fungal infection can rarely spread along lymphatic channels from a primary cutaneous lesion.

Cat scratch disease

A bacterial infection (Bartonella henselae) that starts with a papule at the scratch site, followed by tender regional lymphadenopathy, which can have an element of lymphangitis.

Leishmaniasis

The parasitic infection can spread along lymphatics from the primary ulcer, causing a chain of subcutaneous nodules.

Lymphangitis

A bacterial infection (usually streptococcal) of the lymphatic channels, presenting as painful, red, linear streaks extending from a wound towards regional lymph nodes.

Nocardiasis

A bacterial infection that can cause a primary skin abscess or nodule, with frequent spread along lymphatics to form a chain of nodules and abscesses.

Sporotrichosis

The classic cause, a fungal infection that presents as a nodule at the site of inoculation which ulcerates and is followed by a characteristic painless chain of secondary nodules along the draining lymphatic vessels.

Tularemia

A bacterial infection that can cause an ulcerative lesion at the inoculation site, with associated tender lymphadenopathy and lymphangitis.

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