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Allergic contact dermatitis

Presents as intensely pruritic, poorly demarcated erythema and edema, sometimes with vesiculation, corresponding to an area of allergen contact.

Angiokeratoma

Presents as multiple, small, dark-red to purple papules with a slightly warty surface, typically on the labia majora.

Bartholin cyst

A tense, painful, fluctuant swelling is located posterolaterally at the base of the labia minora.

Bowen's disease

A persistent, solitary, well-demarcated, erythematous, scaly or crusted plaque representing squamous cell carcinoma in situ.

Bowenoid papulosis

Multiple small, reddish-brown or violaceous, flat-topped papules are seen, representing a form of HPV-related intraepithelial neoplasia.

Candidiasis

Bright red, moist erythema of the vulva and introitus is accompanied by thick, white, 'cottage cheese' discharge and often satellite pustules.

Eczema

Poorly demarcated, erythematous patches with scale, weeping, or lichenification from chronic scratching.

Epidermoid cyst

A firm, mobile, skin-colored subcutaneous nodule, which may have a central punctum and can become inflamed.

Erosive lichen planus

Presents as intensely painful, bright red, glassy erosions of the vestibule and vagina, often with a white, lacy border.

Erythema multiforme

Targetoid lesions with dusky centers and red borders can appear on the vulva alongside lesions elsewhere on the body.

Extramammary Paget's disease

A persistent, well-demarcated, erythematous, eczematous-appearing plaque with weeping and crusting, typically in older women.

Genital warts

Presents as multiple, soft, skin-colored or pink, cauliflower-like (exophytic) or flat-topped papules.

Hidradenitis suppuritiva

Recurrent, painful, inflammatory nodules and abscesses with sinus tract formation and 'tombstone' comedones appear in intertriginous areas.

Lichen planus

Violaceous, flat-topped, polygonal papules, sometimes with fine white (Wickham's) striae, appear on the keratinized skin of the vulva.

Lichen sclerosus

Porcelain-white, atrophic, 'cigarette paper' plaques are seen in a figure-of-eight distribution around the vulva and anus, leading to scarring and architectural loss.

Lichen simplex chronicus

Thickened, leathery, hyperpigmented plaques with exaggerated skin markings result from chronic rubbing and scratching.

Melanoma

An asymmetrical, irregularly bordered, variably colored (brown, black, blue, red) macule, papule or nodule that may be ulcerated.

Molluscum contagiousum

Multiple small, skin-colored, dome-shaped papules with characteristic central umbilication.

Mucous membrane pemphigoid

Chronic, painful erosions and desquamative gingivitis that heal with significant scarring, potentially leading to vaginal stenosis.

Psoriasis

Well-demarcated, bright red, non-scaly plaques are located in the vulvar and inguinal folds (inverse psoriasis).

Pubic lice

Pruritus is accompanied by visible nits attached to pubic hair shafts and tiny adult lice or bluish macules (maculae caeruleae) on the skin.

Squamous cell carcinoma

A persistent, firm, indurated plaque, nodule, or ulcer, often arising from a background of lichen sclerosus or VIN.

Syphilis

A painless, indurated ulcer (chancre) in primary disease or flat, moist, warty-appearing plaques (condylomata lata) in secondary disease.

Tinea

An erythematous, scaly plaque with a raised, active border that spreads onto the inner thighs (tinea cruris), typically sparing the vulva itself.

Vitiligo

Well-demarcated, completely depigmented, white macules and patches appear on the vulva and surrounding skin.

Vulval intraepithelial neoplasia

Presents as white (hyperkeratotic), red, or pigmented discrete papules or plaques that may be multifocal.

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