Don't use Dermol 500 as a leave on moisturiser!

By Dr Magnus Lynch
MA(Cantab) DPhil(Oxon) MRCS FRCP
Consultant Dermatologist & Dermatological Surgeon

Dermol 500 is a widely prescribed antimicrobial emollient, often used for dry and itchy skin conditions like eczema. It moisturises the skin and helping to manage the bacteria that can worsen skin conditions. However, while it is an good soap substitute, I advise patients not to use it as a leave on moisturiser as it can cause irritant dermatitis.

What is the difference between Dermol 500 and other moisturisers?

The key difference lies in its active ingredients. Dermol 500 contains two antimicrobials: * Benzalkonium chloride * Chlorhexidine dihydrochloride

These ingredients are designed to reduce bacteria on the skin surface. It will also hydrate the skin and protect the skin barrier more effectively than soaps, shower gels or plain water which can dry the skin.

Can I use Dermol 500 as a leave-on moisturiser?

While it is licensed to be used as a leave-on emollient, I advise patients not to do this due to the risk of irritant dermatitis. The antimicrobial components when left on the skin can disrupt the barrier causing redness, soreness and irritation.

It is often best used as a soap substitute in shower - apply like a shower gel and was off immediately.

Why is Dermol 500 irritating my skin? The risk of irritant dermatitis

If your skin becomes more red, sore, or itchy after using Dermol 500, you may be experiencing irritant contact dermatitis. This is usually not an allergy (although it is possible to be allergic to these ingredients) but rather a direct irritation of the skin caused by an ingredient.

What are the signs Dermol 500 is causing irritation?

Look out for these signs, especially if they appear or worsen after application:

A burning or stinging sensation
Increased redness or inflammation
Skin feeling tight and uncomfortable
Worsening dryness or peeling despite regular use
Itching that does not improve or intensifies

What should I do if I suspect Dermol 500 is irritating my skin?

The best first step is to stop using it as a leave-on moisturiser. Instead, try using it only as a soap substitute to wash with, and rinse it off immediately.

For your leave-on moisturiser, switch to a bland, simple emollient that does not contain any antimicrobial agents or other potential irritants like fragrances. Good alternatives for a leave-on moisturiser include Cetraben Cream, Doublebase gel or Epaderm Ointment.

Dr. Magnus Lynch, Consultant Dermatologist

About Dr Magnus Lynch

I am a London-based Consultant Dermatologist and Dermatological Surgeon. I am highly experienced in skin cancer diagnosis, Mohs micrographic surgery, acne, rosacea, acne scarring and laser treatments. I studied at the Universities of Cambridge and Oxford, and completed my dermatology training and Mohs fellowship at the prestigious St John’s Institute of Dermatology. I graduated from medical school in 2003 and have worked exclusively in Dermatology since 2012.

I lead a research team at King’s College London investigating the molecular biology of skin cancer. In recent years I have been involved in Media Appearances, including the Channel 5 series 'Skin A&E', where I perform skin surgeries and treat various skin conditions. Filming for the next series has recently completed and the series will be released later in 2025.

My NHS practice is at Guy's Hospital. I consult with private patients at the London Bridge Hospital, OneWelbeck (near to Bond Street station) and on Harley Street. A new consultation is £250. Book A Consultation.

I am the founder of Revessa Health which provides online consultations for acne and rosacea across the UK (see below).