Acute contact dermatitis of the face can cause swelling, but it is accompanied by eczematous changes like vesicles and scaling, which are absent in the deep, non-pitting swelling of angioedema.
This is a cause of angioedema, not a differential diagnosis of the sign itself. It is identified by a history of onset shortly after ingesting a specific food.
This is a chronic, persistent, rubbery swelling of the lips, unlike the acute, transient, and often recurrent episodes of angioedema.
Primary herpes infection can cause significant lip swelling, but it is distinguished by the presence of grouped vesicles or painful erosions.
While causing localized swelling, an insect bite is distinguished by a central punctum (the bite mark) and a more localized, erythematous reaction.
This is another cause of angioedema, identified by a history of exposure to latex products (e.g., gloves) immediately prior to the onset of swelling.
