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Necrobiosis lipoidica

This presents as a waxy, atrophic, yellowish plaque with prominent telangiectasias, typically on the shins, a very different primary lesion than an ulcer.

Neuropathic ulcer

The key differentiator is its location over a pressure point (e.g., sole of the foot) in a patient with sensory loss (neuropathy), and it is typically painless with a calloused border.

Pyoderma gangrenosum

This is an inflammatory ulcer distinguished by its rapid expansion, violaceous (purple), undermined border, and extreme pain, often associated with systemic disease.

Venous ulcer

Distinguished by its location within the "gaiter area" (medial lower leg above the ankle) and the presence of surrounding signs of chronic venous insufficiency, such as edema and hemosiderin staining.

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