A bullous fixed drug eruption can mimic EM, but it is defined by its recurrence in the exact same location each time the offending drug is taken.
This viral illness is distinguished by its characteristic distribution of oval-shaped vesicles on the palms, soles, and in the mouth.
This is another coxsackievirus infection, but it is confined to the posterior oropharynx, causing ulcers and vesicles there, without the widespread skin lesions of EM.
Recurrent herpes is the most common trigger for EM, but uncomplicated herpes presents as grouped vesicles in a single location, not the widespread target lesions of EM.
