Candidal intertrigo is distinguished by its beefy-red color and the presence of characteristic satellite pustules at the periphery, which are absent in Hailey-Hailey.
Darier's is characterized by greasy, hyperkeratotic papules in seborrheic areas, a very different primary lesion than the erosions and maceration of Hailey-Hailey in the flexures.
This is a brownish, dry patch that fluoresces coral-red under a Wood's lamp, unlike the moist, eroded plaques of Hailey-Hailey.
Simple intertrigo is inflammation from friction and lacks the vesicles, erosions, and "dilapidated brick wall" histology that define Hailey-Hailey disease.
Inverse psoriasis is a smooth, non-eroded, sharply demarcated red plaque, unlike the macerated and fissured appearance of Hailey-Hailey.
This variant of pemphigus presents with larger, vegetative, malodorous plaques, a more hypertrophic process than the erosions of Hailey-Hailey.
This is a drug eruption, distinguished by its acute onset after medication administration and its symmetric distribution.
Tinea cruris has a raised, scaly, advancing border and is confirmed by a positive KOH test, unlike Hailey-Hailey.
