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Acquired bilateral naevus of Ota-like macules

Also known as Hori's nevus, this is a dermal pigmentation, giving it a bluish-grey hue, unlike the brownish, epidermal pigmentation of melasma.

Actinic lichen planus

This photosensitive variant of LP presents with annular or pigmented plaques in sun-exposed areas, but often has a subtle violaceous hue not seen in melasma.

Cutaneous mercury deposits

This is a rare cause of pigmentation, distinguished by a history of using mercury-containing creams and a slate-grey discoloration.

Drug induced pigmentation

This is distinguished by a history of starting a new medication known to cause hyperpigmentation (e.g., minocycline), which often has a different pattern or color (e.g., bluish-grey).

Erythema dyschromicum perstans

Also called ashy dermatosis, this is characterized by asymptomatic, slate-grey patches that may have an initial, fine, erythematous border, a different color than the brown patches of melasma.

Erythromelanosis follicularis faciei et colli

This is a rare condition characterized by the triad of well-demarcated erythema, hyperpigmentation, and follicular papules on the face and neck.

Exogenous ochronosis

This is a paradoxical, dark, caviar-like pigmentation caused by the long-term use of hydroquinone creams, a specific iatrogenic cause.

Lichen planus pigmentosus

This condition presents with slate-grey to dark brown macules, often in sun-exposed areas but also commonly in flexures, and lacks the classic hormonal triggers of melasma.

Pigmented contact dermatitis

Also known as Riehl's melanosis, this is a reticulated, greyish-brown pigmentation on the face and neck caused by an allergic reaction to a fragrance or chemical.

Poikiloderma of Civatte

This is a common condition on the sides of the neck, distinguished by its triad of mottled hyperpigmentation, telangiectasias, and slight atrophy, characteristically sparing the shaded area under the chin.

Post inflammatory hyperpigmentation

This is distinguished from melasma by a clear history of a preceding inflammatory event, such as acne or a dermatitis, in the affected area.

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