This presents as a fleshy, reddish nodule, but biopsy shows a dense lymphocytic infiltrate, not the amorphous, eosinophilic deposits of amyloid.
Subcutaneous GA presents as deep, firm nodules, but they are typically non-waxy and are composed of palisaded granulomas on histology.
A cutaneous lymphoma nodule is a malignant proliferation of lymphocytes, whereas nodular amyloidosis is a deposition of amyloid light chains.
Multicentric reticulohistiocytosis presents with reddish-brown nodules and a destructive arthritis, a different clinical picture.
Subcutaneous sarcoid nodules are firm and non-waxy, and biopsy shows classic non-caseating granulomas.
