Aphthous ulcers are discrete, self-limited ulcers, unlike the extensive, persistent, and fragile erosions that characterize the oral onset of pemphigus.
The ulcers of Behcet's are "punched-out" and recurrent but not typically as widespread and erosive as in pemphigus, and Behcet's is defined by other systemic features (genital ulcers, uveitis).
BP is distinguished by its large, tense, intact bullae on the skin, whereas pemphigus has superficial, flaccid bullae that rupture very easily, leaving widespread erosions.
Mucositis from chemotherapy is an acute event related to drug administration, not a chronic autoimmune disease.
This is an endemic form of pemphigus foliaceus in Brazil, which is more superficial and crusted, lacking the deep oral erosions of pemphigus vulgaris.
This is an acute, widespread blistering reaction to a drug, which resolves on cessation, unlike the chronic autoimmune nature of pemphigus.
This is a pustular or vesicular disease, often with an annular pattern, and is defined by IgA deposits on immunofluorescence, not the IgG seen in pemphigus vulgaris.
MMP is a subepidermal blistering disease that causes scarring, particularly of the eyes and oral cavity, whereas pemphigus is an intraepidermal disease that typically does not scar.
This is a severe variant associated with an underlying malignancy (often lymphoma), distinguished by its severe, intractable stomatitis and polymorphic skin lesions.
This is a blistering disease of pregnancy, a specific clinical context not required for pemphigus.
This is an overlap syndrome of pemphigus and lupus, distinguished by having features of both, such as a malar rash and positive ANA, along with pemphigus antibodies.
This is a more superficial form of pemphigus, causing crusted, scaly erosions on the skin ("cornflake scale") and characteristically sparing the mucous membranes.
This is a variant of pemphigus vulgaris, distinguished by the development of hypertrophic, vegetative, malodorous plaques in intertriginous areas.
SJS is an acute, severe reaction to a drug, characterized by targetoid lesions and widespread mucosal sloughing, a different clinical picture than chronic autoimmune pemphigus.
