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Bowen's disease

This is a persistent, scaly plaque of SCC in situ, unlike the acute, bright red, moist infection of perianal strep.

Candida

Perianal candidiasis is distinguished by its beefy-red color and the presence of satellite pustules.

Eczema

Perianal eczema is typically less well-demarcated and more scaly or weepy than the uniform, bright red erythema of a strep infection.

Extramammary Paget's disease

This is a persistent, eczematous-appearing plaque that is unresponsive to therapy, representing an underlying adenocarcinoma.

Lichen simplex

This is a thickened, leathery plaque from chronic scratching, not an acute, bright red infection.

Pruritus ani

This is the symptom of itching, which can be caused by a strep infection, not a differential diagnosis of the appearance.

Psoriasis

Inverse psoriasis in this area is a sharply demarcated red plaque, but it is typically not as moist or tender as a strep infection and is chronic.

Seborrhoiec dermatitis

This would be less intensely erythematous and have a more yellowish, greasy scale.

Tinea

A fungal infection here would have a scaly, advancing border and be confirmed by a KOH test.

lichen sclerosus

This is characterized by atrophic, porcelain-white plaques, a completely different appearance.

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