This is another genetic syndrome with multiple lentigines, but it is distinguished by its association with cardiac myxomas and other endocrine tumors.
The mucocutaneous lesions in HHT are telangiectasias (small, blanching red spots), not the brown-to-black macules (lentigines) of Peutz-Jeghers.
This refers to a single lesion; Peutz-Jeghers is a syndrome defined by multiple lentigines in a characteristic periorificial distribution, associated with intestinal polyps.
