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Acrochordon

Also known as a skin tag, this is a soft, pedunculated papule typically found in frictional areas, unlike the 'stuck-on' keratosis.

Acrokeratosis verruciformis

Presents as multiple, flat-topped, skin-colored papules resembling plane warts, primarily on the dorsum of the hands and feet.

Basal cell carcinoma

Can be pigmented, but typically has a pearly, translucent quality and telangiectasias, and may have central ulceration, unlike a seborrheic keratosis.

Compound naevus

A benign mole that is typically smooth, symmetric, and dome-shaped, lacking the warty or 'stuck-on' surface of a seborrheic keratosis.

Dermatofibroma

A firm, dermal nodule that characteristically 'dimples' or retracts downwards when squeezed from the sides.

Dermatosis papulosa nigra

Presents as multiple, small, hyperpigmented, pedunculated papules on the face and neck of individuals with darker skin types, essentially small seborrheic keratoses.

Eccrine poroma

A benign sweat gland tumor, often appearing as a pink or red, moist, vascular-appearing papule or nodule, typically on the sole of the foot.

Intradermal naevus

A flesh-colored or lightly pigmented, dome-shaped, soft papule, which represents a mole deep in the dermis and lacks a warty surface.

Junctional naevus

A flat (macular), uniformly pigmented mole, representing melanocytes at the dermal-epidermal junction, unlike the raised keratosis.

Pigmented basal cell carcinoma

Distinguished by features like telangiectasia, a pearly border, or ulceration, which are absent in a seborrheic keratosis.

Squamous cell carcinoma

An indurated, firm papule or nodule with surface scale or ulceration, which feels much harder than a soft seborrheic keratosis.

Stucco keratoses

Small, white or gray, 'stuck-on' papules found on the lower legs and ankles of older individuals, which are easily scraped off.

Verrucous melanoma

A rare melanoma subtype that can mimic a seborrheic keratosis but is distinguished by irregular pigmentation, growth, or bleeding, and confirmed by biopsy.

Viral wart

Has a verrucous surface but often shows thrombosed capillaries (black dots) and disrupts normal skin lines.

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