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Erythema annulare centrifugum

Presents with annular, erythematous plaques with a characteristic 'trailing scale' on the inner border, and is not associated with photosensitivity or autoantibodies.

Granuloma annulare

Annular plaques of skin-colored papules, typically on the hands and feet, which are firm and lack the scale or photosensitivity of SCLE.

Pemphigus foliaceus

An autoimmune blistering disease with superficial, crusted erosions in a seborrheic distribution, caused by autoantibodies to desmoglein 1.

Polymorphic light eruption

A pruritic papular or eczematous eruption that occurs hours to days after sun exposure and resolves completely, unlike the more persistent lesions of SCLE.

Prebullous pemphigus

Presents as urticarial, eczematous, or annular plaques that are intensely pruritic and precede the formation of tense bullae.

Psoriasis

Presents with well-demarcated, erythematous plaques with a thick, silvery scale, a different morphology from the annular or papulosquamous lesions of SCLE.

Rosacea

Confined to the central face, with papules, pustules, and telangiectasias, but lacks the annular plaques and positive Ro/SSA antibodies of SCLE.

Sarcoidosis

Can present with annular lesions, but they are typically composed of firm, reddish-brown papules and biopsy shows non-caseating granulomas.

Tinea

An annular fungal infection with a raised, scaly, active border that can be confirmed with a KOH preparation.

Urticaria

Presents as transient, pruritic wheals that last for hours, not the persistent, photosensitive plaques of SCLE.

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