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AGEP

An acute pustular eruption, not a blistering or sloughing one, though both are severe drug reactions.

DRESS syndrome

Also a severe drug reaction, but characterized by a morbilliform eruption, marked eosinophilia, and systemic organ involvement, without the widespread epidermal necrosis of TEN.

Erythema multiforme

EM major can have mucosal involvement, but is defined by typical target lesions and less than 10% BSA detachment.

Generalized bullous fixed drug eruption

A rare drug reaction with widespread bullae, but these arise on the characteristic dusky plaques of a fixed drug eruption and have a different histology.

Graft versus host disease

Acute GVHD can cause a TEN-like eruption, but is distinguished by its occurrence in a patient who has received an allogeneic stem cell or organ transplant.

Linear IgA disease

An autoimmune blistering disease that can be drug-induced, but is characterized by annular arrangements of vesicles ('string of pearls') and linear IgA deposition on biopsy.

Paraneoplastic pemphigus

A rare, severe blistering disease associated with an underlying malignancy, characterized by severe, intractable stomatitis and polymorphic skin lesions.

Staphylococcal scalded skin syndrome

Causes widespread epidermal sloughing, but typically affects young children, spares mucous membranes, and has a very superficial cleavage plane within the epidermis.

Stevens Johnson syndrome

Considered a less severe variant of the same disease, defined as having less than 10% body surface area detachment.

TEN like lupus

A rare presentation of acute cutaneous lupus that can mimic TEN, but occurs in patients with known lupus and is distinguished by specific immunofluorescence findings.

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