An acute pustular eruption, not a blistering or sloughing one, though both are severe drug reactions.
Also a severe drug reaction, but characterized by a morbilliform eruption, marked eosinophilia, and systemic organ involvement, without the widespread epidermal necrosis of TEN.
EM major can have mucosal involvement, but is defined by typical target lesions and less than 10% BSA detachment.
A rare drug reaction with widespread bullae, but these arise on the characteristic dusky plaques of a fixed drug eruption and have a different histology.
Acute GVHD can cause a TEN-like eruption, but is distinguished by its occurrence in a patient who has received an allogeneic stem cell or organ transplant.
An autoimmune blistering disease that can be drug-induced, but is characterized by annular arrangements of vesicles ('string of pearls') and linear IgA deposition on biopsy.
A rare, severe blistering disease associated with an underlying malignancy, characterized by severe, intractable stomatitis and polymorphic skin lesions.
Causes widespread epidermal sloughing, but typically affects young children, spares mucous membranes, and has a very superficial cleavage plane within the epidermis.
Considered a less severe variant of the same disease, defined as having less than 10% body surface area detachment.
A rare presentation of acute cutaneous lupus that can mimic TEN, but occurs in patients with known lupus and is distinguished by specific immunofluorescence findings.