Metronidazole not working for rosacea after 8 weeks - what next?

If metronidazole is going to work, most people notice an improvement within 4 to 8 weeks, with the maximum benefit by about 12 weeks. If there has been little change after 8 to 12 weeks of daily use, it is reasonable to move on. The right next step depends on which features of rosacea are still there.

Spots and bumps still present

Ivermectin (Soolantra) is, in my experience, the most effective cream for the inflammatory spots of rosacea, and it often works where metronidazole has not. Azelaic acid is an alternative. Where spots are widespread, or the eyes are affected, a few months of an oral tetracycline such as lymecycline settles the inflammation, after which a cream can often maintain control.

Mainly redness

If the spots have gone but the face is still red, the cause is usually dilated blood vessels, which no cream removes. Vascular laser treats these directly.

Is it definitely rosacea?

When a rosacea treatment does not work, it is worth checking the diagnosis. Perioral dermatitis, seborrhoeic dermatitis, steroid-induced rosacea and acne can all look similar, and some are made worse by the wrong treatment. A skincare routine containing irritants can disturb the skin barrier, keeping rosacea active.

Metronidazole not working?

I can confirm the diagnosis, identify which features of your rosacea are still active, and set out the treatments most likely to work. Consultations can be in person or remote.

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Dr Magnus Lynch

About Dr Magnus Lynch

MA(Cantab) DPhil(Oxon) MRCS FRCP

I am a London-based Consultant Dermatologist and Dermatological Surgeon. I am highly experienced in skin cancer diagnosis, Mohs micrographic surgery, acne, rosacea, acne scarring and laser treatments. I studied at the Universities of Cambridge and Oxford, and completed my dermatology training and Mohs fellowship at the prestigious St John's Institute of Dermatology. I graduated from medical school in 2003 and have worked exclusively in Dermatology since 2012.

I lead a research team at King's College London investigating the molecular biology of skin cancer. In recent years I have been involved in Media Appearances, including the Channel 5 series 'Skin A&E', where I perform skin surgeries and treat various skin conditions.

My NHS practice is at Guy's Hospital. I consult with private patients at OneWelbeck (near to Bond Street station), on Harley Street and at The Shard (London Bridge). Book A Consultation.

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I am available for consultations at several sites in Central London. Some conditions such as acne and rosacea are also suitable for a remote consultation with photos. Either enter your details and my practice management team will contact you within 1 working day or use instant online booking. Alternatively you can call or email directly. Please note that not all open clinic slots are visible on the instant booking link.

I see adults aged 18 and over. I do not offer patch testing for allergies, or tablet and injection treatments for eczema or psoriasis.

Central London • Harley Street
Mon – Fri, 9am – 5pm

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