Lymecycline not working for acne after 3 months - what next?

Lymecycline is usually prescribed for about three months, often in combination with a cream, before judging the response. If acne is still active after that, or recurs rapidly, then switching to another antibiotic rarely helps. The next step is usually isotretinoin for moderate, scarring or persistent acne, hormonal treatment for women whose acne is around the jawline and chin, or the Aviclear laser.

Was it given a fair trial?

Antibiotic tablets work best combined with a cream such as a topical retinoid or benzoyl peroxide, which also helps the result last after the tablets stop.

Why switching antibiotic rarely helps

Antibiotic tablets can be very effective for mild or moderate acne, however acne can recur when they are discontinued. If one antibiotic has not worked, another usually adds little, and repeated courses increase the risk of bacterial resistance.

Possible next steps

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Dr Magnus Lynch

About Dr Magnus Lynch

MA(Cantab) DPhil(Oxon) MRCS FRCP

I am a London-based Consultant Dermatologist and Dermatological Surgeon. I am highly experienced in skin cancer diagnosis, Mohs micrographic surgery, acne, rosacea, acne scarring and laser treatments. I studied at the Universities of Cambridge and Oxford, and completed my dermatology training and Mohs fellowship at the prestigious St John's Institute of Dermatology. I graduated from medical school in 2003 and have worked exclusively in Dermatology since 2012.

I lead a research team at King's College London investigating the molecular biology of skin cancer. In recent years I have been involved in Media Appearances, including the Channel 5 series 'Skin A&E', where I perform skin surgeries and treat various skin conditions.

My NHS practice is at Guy's Hospital. I consult with private patients at OneWelbeck (near to Bond Street station), on Harley Street and at The Shard (London Bridge). Book A Consultation.

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I am available for consultations at several sites in Central London. Some conditions such as acne and rosacea are also suitable for a remote consultation with photos. Either enter your details and my practice management team will contact you within 1 working day or use instant online booking. Alternatively you can call or email directly. Please note that not all open clinic slots are visible on the instant booking link.

I see adults aged 18 and over. I do not offer patch testing for allergies, or tablet and injection treatments for eczema or psoriasis.

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